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Metabolic characteristics include: Plasma half-life of 11-12 minutes after either intravenous or subcutaneous administration Very rapid clearance rates of 2.4-2.8 L/min in adult subjects Degradation primarily through peptidase enzymes in plasma and tissues No accumulation observed even with repeated daily dosing The extremely short half-life reflects the peptides susceptibility to proteolytic cleavage at multiple sites along its amino acid sequence

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The IIEF score was 28 (normal range 2630)

Research characterizes its modulation of the nitric oxide system and promotion of angiogenesis upregulating VEGF signaling and supporting endothelial function as a unifying mechanism linking its diverse tissue-repair effects 5